![]() ![]() ![]() Compression is further achieved by joining contiguous non-variant regions with similar properties into single ‘block’ VCF records. ![]() GVCF is a text file format, stored as a gzip compressed file (*.). If you are performing targeted sequencing, gVCF is also an appropriate choice to represent and compress the results. Typical human whole-genome sequencing results expressed in gVCF with annotation are less than 1 Gbyte, or about 1/100 the size of the BAM file used for variant calling. These conventions allow representation of genotype, annotation, and other information across all sites in the genome in a compact format. gVCF is a set of conventions applied to the standard variant call format (VCF) 4.1 as documented by the 1000 Genomes Project. gVCF was developed to store sequencing information for both variant and non-variant positions, which is required for human clinical applications. This application also produces the Genome Variant Call Format file (gVCF). ![]()
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